Just a random thought more than a firm POV, but I'd suggest that for any renaissance to happen we need to find an acceptable middle ground that makes the games sellable today.
I just had a playthrough of A Bard's Tale 4 cut short about halfway through due to corrupted saves, but up until that point was absolutely loving it. It was a superb blend of old and new, with most gameplay evolutions being understandable, enjoyable or at worst bearable, with most options adjustable.
Dragon Age: Origins was another example. Course I'd sooner have an isometric, turn-based view, but that's not gonna snag the sales which DA:O did for it's more mainstream approach. But it worked well and still held to it's core values enough to be enjoyable. What they should have done is then moved the game back towards it's roots with each entry, as opposed to popamoleyo.
Fuck knows how it'd happen now though. But Bard's Tale 4 really felt like a great step in the right direction.
I think an isometric, turn-based RPG with smart art design, good mechanics, quality-of-life improvements, (and most importantly) good writing, will sell very well.
I'm not just saying that because it's my specific wheelhouse, but because in my experience and interaction with other devs/players, it's what the market is really craving right now.
Ultimately, I think it really comes down to talent. One or two more great games that satisfy codex preferences will tip the scales and bring popular opinion here around. Maybe if KCD's sequel knocks it out of the park, or Colonyship, or something else. Even grognards appreciate good craftsmanship.