Well, here - it isnt about playing a "girl". Just like it wasnt in Fallout.
No need to be transexual or manly at all - because of it.
You certainly werent in Fallout.
This is far future, post technological singularity setting.
Human body modification is one of the regularly manifesting things.
The player may be a member of some community that was modified eon ago, still carrying those traits, but without being overpowered. Just - different.
But internally, on cellular level, rather then on the outside.
A PC can be some modified android or clone who woke up without memory.
Or someone waking up from cryogenic stasis.
You can even start equally weak.
and then choose, gain and improve attributes, abilities and skills you choose - through gameplay.
Of course, if you can choose what you want in char gen then you can pick attributes as you please., in the first place.
Then again, even if you start with gender differences there is enough in setting to provide you with modifications.
Run into a specific nano swarm and it could modify or remake you. Achieve alterations to attributes through quests and subquests. By discovering old technology, lost knowledge, powerful "friends".
Or achieve it through equipment, items, artifacts, "drugs"..... And it can all have pros and cons included.
With further C&C.
Loads of options, really.
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besides, we already know there wont be filler combat and grinding.
