Hard-locked the MQ ~17 hours in; judging by the mission list I'm nearly halfway through the story. I liked a lot about it, but it's a tough pill to swallow when there's so much lacking and underdeveloped. Going to shelve it for now.
The world feels dead, which is a problem when it's so large and there's very limited fast travel (might be story reasons or a bug, but the only travel option I have atm is to the Slag Heap, and even if you could pay neutral stalkers in the field to guide you it wouldn't be a fix because I've seen next to none wandering around). Feels like you're just running from one quest location to another. Missions are often far away, and you may go 5-10+ minutes running around without seeing any humans or mutants. Nothing is ever in the distance; I don't know why they even included snipers when everything spawns next to you. Makes sense they got rid of the binoculars.
Gear degradation feels a little too taxing. Weight limit/fatigue is also punishing when you have to go kilometers to stuff away or sell your junk. Loot is much too plentiful and the economy makes zero sense. Human AI is decent at times and impressively stupid in others. AI is completely incompetent at fighting itself but pinpoint when it comes to you. Stealth feels broken. No reward for wasting time/money on mutants (they could also use a 10-20% hp debuff to make them slightly less tedious). Radiation on-screen effect is overwhelming. Constant bleeding. Long animations I frequently interrupted at the last frame (like bandaging). If there is a complex faction/reputation system I didn't notice it. People don't acknowledge that you revived them. Can't control length of sleep. No NVG and the flashlight sucks for how dark the game is; days should be a little longer if they're going to be gloomy half the time anyways. No ranking systems or chatter. Placeholder descriptions that somehow made it through QA. Have to edit the .ini to get rid of mouse smoothing and other visual effects. Experienced small annoying bugs, but at least they would go away on reload (a few times I got stuck doing the corner peak when I left the wall, couldn't run, had weird objects floating off my gun, wall textures breaking, etc). I feel like I could go on and on. I'd suggest waiting at least a year or two to see if they fix it.