On topic of synergies, i didn't go indepth but I feel like INT is best combat stat at least for highest hp bloat difficulty
you want to do steady, reliable damage, both single target and aoe. Luck also looks fun tho. My favorite gun is just a pistol with +max range scope, favorite stat INT, and does it make sense to give Sneak Shit to everyone including level 10 perk? well I guess it does if you have Explosives, it's just that a sneak specialist with giant missile launcher (and 1 point of strength) didn't feel logical to me
then again rambo did it, and sabouteurs with explosives do exist eh.