Man, i wish that after the main campaign we could just fuck of into the unknown, like act 5 but without stupid inquisitor shit, maybe you accidentally somehow warp to the edge of galaxy and you must now return to your space.
I just read about halo stars and considering how close our sector is, this would be a great opportunity to have this lost in space vibe, probably with roguelike exploration, explorable space hulks, some eldtrich shit, new mysterious xeno worlds and monsters, surviving/ broken men of iron or some another kind of abominable intelligence, forgotten human colonies etc. Maybe planets with some surviving dark age of technology stuff intact, though i guess some would find functioning pre age of strife stable society against the setting. I guess you could balance this by making such planet populated with only small amount of people, withering, stagnating and thanks to their technological ascension detached from life/ being so gene edited and/or mutated beyond any human resemblance/ being on the brink of destruction and our arrival accidentaly(or maybe not so accidentally, why not) eithers propels them to it or we could arrive at the right moment to just watch it happen.
This would also give creators opportunity to be more creative outside of classic WH40k stuff, who knows what really is there after all, though im not sure if Owlcat would be up to the task, without them adding some cringe gay bullshit.