PSA: MO2 works very well with CP2077 now. There are instructions
here, it's pretty easy (two ways of doing it, either with Root Builder plugin for MO2 or just by manually installing CET and Red4ext, and having everything else in MO2). Root Builder does work very well now, but it's probably wiser to do the manual install for those two core mods.
One thing to note: the usual best practice for Skyrim doesn't work here. You can't make a mod out of everything that goes into Overwrite,
you have to leave everything that crops up in Overwrite in Overwrite, otherwise things like settings changes in Native Loader don't stick.
Best visual tweak (even without all the RT palaver, which I can't use) is the combination of the
Natural Californian Lighting mod and a light,
subtle Reshade that was made for it, seen in full glory here:-
It tones down the slightly cartooney, garish look of vanilla and in daytime sunny weather makes the game look like it's really set in sun-baked California - you can almost
feel the heat
IOW it makes NC seem more like a real place (Bladerunner rainy neon-lit noir nights are still present and correct and there are several mods that make that vibe more frequent).
I've played around with a few gameplay mods for 2.01 (the damage scaling part of
this mod, with its recommended curve, and a mod that makes the
guns more "realistic"), and while they do make Very Hard harder, I've been finding that the game is pretty well tuned now as is, in terms of difficulty. VH is good enough - after all, it's not really a tactical game, more of a fun romp, and Very Hard now gives you just enough challenge so that you can't easily faceroll the combat - enemy hits do take great chunks out of you quite easily if you're not alert - without making every fight too long and tedious. But if you do want every fight to be epic, those two combined are the only ones doing that atm.
There's also an HD Reworked (AI upscaling) and a few mods that make the adverts, vending machines and all that more hi-rez, both of which are very good.
Apart from that, there are tons of QOL tweak mods to suit everybody's tastes, and of course all sorts of graphics and tiddy mods. The best QOL mod is probably
Custom Quickslots - really very, very handy indeed, makes it much less fiddly taking your Jolt, using your usables and switching out grenades and whatnot, or your food and drink if you're using the
survival system mod (which is quite nice and simple). (Top tip: you can make the icons as small as the telephone and car icons bottom left, they take up less screen real estate that way).
The modding scene really hasn't quite caught up with the updates. I mean, the core mods have, and a lot of the QOL/tweakey ones have, but last time I played with 1.61, there was a whole ecosystem of quite creative modding going on (e.g. the drone/robot companion mod), but all those mods are broken now, and some of them will probably take a while to come back, if ever. But as I said earlier in the thread, it's quite clear that CDPR used a lot of the more popular mods of that types as inspiration (e.g. the police alert system mod), so there's that.
Another neat mod worth mentioning is
GTA Travel (which can be set as from anywhere to travel point, or anywhere to anywhere), which does a great zoom out/zoom in. There was a version of this mod when I was playing 1.61 but it was a bit janky, this time round it seems to be smooth and flawless (had only one crash - of the mod, not the game, and if the mod crashes it just reloads the game and puts you where you wanted to be -in the time I'd have had like 5 with the previous versions).
Oh, and a cool mod that's just been updated:
Deadly Roads - makes car crashes more dangerous and being run over often fatal. Don't Walk!
Realistic Car Crashes pairs nicely with that.